The best Side of cees dekker
The best Side of cees dekker
Blog Article
Rotary movement of DNA rotors on nanopores. Prime row: raw online video in the Cy5 channel of each rotor. Middle row: corresponding single-particle localization final results of both of those finishes from the DNA rotors. The place of the current frame is marked as orange and blue dots, plus the trajectory of the 10 frames prior to The present body is shown as solid traces.
Human Rad51 filaments on double- and solitary-stranded DNA: correlating normal and irregular varieties with recombination operate.
[Laughs] ‘It was definitely a great risk! At the time, I had been perfectly informed that it could go Erroneous Which I could grow to be much less effective, but I just dismissed that. Curiosity has always been my strongest driving power. And luckily all of it labored out.’
2007, 1st real-time detection of strand exchange in homologous recombination by RecA; discovery of the low persistence size of finishes of microtubules; and fixed the mechanism of biosensing with carbon nanotubes
This yielded a breakthrough. Inside of only some months, we have been able to evaluate transport by means of someone single-walled carbon nanotube. Determined by reduced-temperature experiments by an excellent PhD student in my team, Sander Tans (now a valued colleague and professor at Delft College of Technological innovation with an Energetic investigate lab at AMOLF in Amsterdam), we showed that carbon nanotubes ended up genuine quantum wires with quite long (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic conduct.
The coiled-coil of your human Rad50 DNA mend protein consists of unique segments of enhanced flexibility
We use nanofabricated microfluidic constructions to pattern spatial boundaries for microorganisms and biomimetic vesicles with reconstituted protein networks and this assess the fundamental part of spatial confinement on the molecular and cellular level. Our projects include the subsequent:
Move-driven rotary motors like windmills and drinking water wheels push purposeful procedures in human society. Even though examples of these kinds of rotary motors also aspect prominently in mobile biology, their artificial construction on the nanoscale has remained demanding. Below we display movement-driven rotary motion of a self-organized DNA nanostructure which is docked onto a nanopore in a thin sound-condition membrane. An elastic DNA bundle self-assembles into a chiral conformation upon phoretic docking onto the sound-condition nanopore, and subsequently displays a sustained unidirectional rotary motion of up to 20 rev s−1.
The rotors harness Strength from a nanoscale h2o and ion stream which is generated by a static chemical or electrochemical opportunity gradient from the nanopore, that happen to be proven through a salt gradient or utilized voltage, respectively. These artificial nanoengines self-Manage and function autonomously in physiological circumstances, suggesting tips on how to setting up energy-transducing motors at nanoscale interfaces.
But carbon nanotubes have remained a research topic of considerable desire to lots of. In truth, the outlook on applying carbon nanotubes to make simple equipment, in parts for instance radio-frequency electronics, electronic electronics and flexible electronics, remains dazzling.
[fourteen] In 2005 Dekker became involved with Netherlands-broad conversations about Intelligent Layout, a motion that he has given that Evidently distanced himself from. Dekker advocates that science and religion are certainly not in opposition but may be harmonized.
1999, to start with measurement in the wavefunction of one molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence https://www.ceesdekker.net for the new Luttinger description of interacting electrons in nanotubes
Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of one wire bridging two electrodes
Case in point (2) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in grey, the rim in the pore is highlighted in pink, as well as a 3D rendering from the movement of the DNA rod is shown.