ceesdekker.net for Dummies
ceesdekker.net for Dummies
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Human Rad51 filaments on double- and one-stranded DNA: correlating regular and irregular kinds with recombination functionality.
[Laughs] ‘It absolutely was surely an incredible possibility! At enough time, I used to be effectively mindful that it could go Mistaken and that I could turn out to be much less successful, but I just disregarded that. Curiosity has generally been my strongest driving pressure. And fortuitously it all labored out.’
Our do the job was immediately adopted up by others, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 printed their findings on transistors produced from single- and multi-walled carbon nanotubes in Applied Physics Letters.
This yielded a breakthrough. In only a few months, we ended up in a position to evaluate transportation by way of an individual solitary-walled carbon nanotube. Based on very low-temperature experiments by a brilliant PhD scholar in my group, Sander Tans (now a valued colleague and professor at Delft University of Technology using an Lively analysis lab at AMOLF in Amsterdam), we confirmed that carbon nanotubes were authentic quantum wires with pretty extended (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic behaviour.
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of just one wire bridging two electrodes
‘In the beginning we checked out Organic methods by using a Actual physical view and acted on the basis on the tools we knew. It took a several years in advance of we started Functioning additional on the massive Organic problems. I then started to phone it nanobiology, a expression that didn't exist at some time.
2011, to start with in vitro measurements of transportation throughout one biomimetic nuclear pore advanced; progress of multiplexed magnetic tweezers for kilo-molecule experiments; and solved the mechanism of homology recognition in DNA homologous recombination
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Bulk-surface area coupling identifies the mechanistic link involving Min-protein patterns in vivo and in vitro
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Nature Physics many thanks the anonymous reviewers for his or her contribution to your peer assessment of the operate.
By way of example, we look at the nucleopore complex, a gateway concerning the mobile nucleus and also the cytoplasm. This is a really challenging program and therefore tricky to examine inside a mobile, so we use biomimetics. We reconstruct holes after which insert individual features on the nucleopore complicated to check transport as a result of it at The only-molecule amount.’
Finally, I will briefly sketch some of our Suggestions to investigate the creating of artificial cells, specially our to start with ways to determine artificial mobile division.